产品详情
简单介绍：
Anti-IDE抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-IDE抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Mouse Anti-IDE
Cat. Number:
Anti-IDE抗体KL-0018M
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and
Anti-IDE抗体mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.
Also known as:
BC2; Insulin degrading enzyme; FLJ35968;
Anti-IDE抗体insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.
Specificity:
●
Mouse Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Chicken, Pig, Cow, .
●
Immunogen: KLH conjugated synthetic peptide derived from human IDE.
●
Predicted Molecular Weight: 117kDa.
Anti-IDE抗体
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500
Not yet tested in other applications. Anti-IDE抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-IDE抗体
Optimal working dilutions must be determined by the end user.
kl826Po01 胰腺型磷脂酶A2(pPLA2)多克隆抗体 Polyclonal Antibody to Phospholikle A2, klcreas (pPLA2)
kl827Hu01 ⅡA组磷脂酶A2(PLA2G2A)多克隆抗体 Polyclonal Antibody to Phospholikle A2, Group IIA (PLA2G2A)
kl841Hu01 磷脂酰肌醇特异性磷酯酶Cγ2(PLCγ2)多克隆抗体 Polyclonal Antibody to Phospholikle C Gamma 2, Phosphatidylinositol Specific (PLCg2)
kl842Hu01 磷脂酶D2(PLD2)多克隆抗体 Polyclonal Antibody to Phospholikle D2 (PLD2)
kl851Hu01 磷脂酶A2受体1(PLA2R1)多克隆抗体 Polyclonal Antibody to Phospholikle A2 Receptor 1 (PLA2R1)
kl853Hu01 天冬氨酸转氨酶2(AST2)多克隆抗体 Polyclonal Antibody to Askltate Aminotransferase 2 (AST2)
kl853Mu01 天冬氨酸转氨酶2(AST2)多克隆抗体 Polyclonal Antibody to Askltate Aminotransferase 2 (AST2)
kl854Hu01 谷丙转氨酶2(ALT2)多克隆抗体 Polyclonal Antibody to Alanine Aminotransferase 2 (ALT2)
kl856Hu01 氨基乙二酸转氨酶(AADAT)多克隆抗体 Polyclonal Antibody to Aminoadikle Aminotransferase (AADAT)
kl861Hu01 磷酸丝氨酸转氨酶1(PSAT1)多克隆抗体 Polyclonal Antibody to Phosphoserine Aminotransferase 1 (PSAT1)
kl864Hu01 谷氨酰胺果糖-6-磷酸转氨酶2(GFPT2)多克隆抗体 Polyclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 2 (GFPT2)
kl870Hu01 血管非炎性蛋白3(VNN3)多克隆抗体 Polyclonal Antibody to Vanin 3 (VNN3)
kl873Hu01 胰岛素样蛋白3(INSL3)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 3 (INSL3)
kl873Mu01 胰岛素样蛋白3(INSL3)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 3 (INSL3)
kl873Ra01 胰岛素样蛋白3(INSL3)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 3 (INSL3)
kl875Hu01 胰岛素样蛋白5(INSL5)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 5 (INSL5)
kl875Mu01 胰岛素样蛋白5(INSL5)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 5 (INSL5)
kl876Mu01 胰岛素样蛋白6(INSL6)多克隆抗体 Polyclonal Antibody to Insulin Like Protein 6 (INSL6)
kl879Hu01 Syncollin蛋白(SYCN)多克隆抗体 Polyclonal Antibody to Syncollin (SYCN)
kl887Hu01 脯氨酸丰富蛋白4(PRR4)多克隆抗体 Polyclonal Antibody to Proline Rich Protein 4, Lacrimal (PRR4)
