产品详情
简单介绍：
Anti-GTF3C4抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-GTF3C4抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-GTF3C4
Cat. Number:
Anti-GTF3C4抗体KL-16360R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires
Anti-GTF3C4抗体the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
Also known as:
EC 2.3.1.48; FLJ21002; General
Anti-GTF3C4抗体transcription factor 3C 4; General transcription factor 3C polypeptide 4; General transcription factor IIIC, polypeptide 4, 90kDa; GTF3C4; KAT12; MGC138450; OTTHUMP00000022434; TF3C delta; TF3C-delta; TF3C4_HUMAN; TFIII90; TFIIIC 90 kDa subunit; TFiiiC2 90; TFIIIC290; TFIIIC90; TFIIICdelta; Transcription factor IIIC 90 kDa subunit; Transcription factor IIIC subunit delta.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human GTF3C4.
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Predicted Molecular Weight: 92kDa.
Anti-GTF3C4抗体
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-GTF3C4抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-GTF3C4抗体
Optimal working dilutions must be determined by the end user.
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