产品详情
简单介绍：
Anti-EME2抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-EME2抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-EME2
Cat. Number:
Anti-EME2抗体KL-14578R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Eme2 is a 379 amino acids nuclear Anti-EME2抗体protein. As a member of the Eme2/Mms4 family, Eme2 associates with MUS81 to constitute a DNA structure-specific endonuclease. The MUS81-Eme2 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3' DNA flaps. Expressed as two alternatively spliced isoforms, Eme2 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. Defects in the gene encoding WDR59 may be associated with the rare disorder Rubinstein-Taybi syndrome or Crohn's disease, which is a gastrointestinal inflammatory condition.
Eme2 is a 379 amino acids nuclear Anti-EME2抗体protein. As a member of the Eme2/Mms4 family, Eme2 associates with MUS81 to constitute a DNA structure-specific endonuclease. The MUS81-Eme2 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3' DNA flaps. Expressed as two alternatively spliced isoforms, Eme2 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. Defects in the gene encoding WDR59 may be associated with the rare disorder Rubinstein-Taybi syndrome or Crohn's disease, which is a gastrointestinal inflammatory condition.
Also known as:
EME1, S. pombe, homolog of, 2; Eme2;
Anti-EME2抗体EME2_HUMAN; essential meiotic endonuclease 1 homolog 2; essential meiotic endonuclease 1, S.pombe, homolog of, 2; essential meiotic structure-specific endonuclease subunit 2; gs125; homolog of yeast EME1 endonuclease 2; Probable crossover junction endonuclease EME2; SLX2 structure-specific endonuclease subunit homolog B; SLX2B.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Pig, Cow, .
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Immunogen: KLH conjugated synthetic peptide derived from human EME2.
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Predicted Molecular Weight:
Anti-EME2抗体41kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-EME2抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-EME2抗体
Optimal working dilutions must be determined by the end user.
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