产品详情
简单介绍：
Anti-Drebrin抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-Drebrin抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-Drebrin
Cat. Number:
Anti-Drebrin抗体KL-5835R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Drebrin is a major neuronal
Anti-Drebrin抗体F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the ***** or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the ***** brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the ***** brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought Anti-Drebrin抗体to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the ***** brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine.
Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the ***** brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought Anti-Drebrin抗体to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the ***** brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine.
Also known as:
D0S117E; DBN 1; DBN1; Developmentally regulated brain protein; Developmentally-regulated brain protein; DKFZp434D064;
Anti-Drebrin抗体DREB_HUMAN; Drebrin 1; Drebrin; Drebrin E; Drebrin1; DrebrinE.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human Drebrin.
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Predicted Molecular Weight: 71kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-Drebrin抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-Drebrin抗体
Optimal working dilutions must be determined by the end user.
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